Toshihiro Horii Selected Research

orotidylic acid

6/2006	Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.
2/2005	A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization.
6/2004	Orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase exist as multienzyme complex in human malaria parasite Plasmodium falciparum.

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Toshihiro Horii Research Topics

Disease

69	Malaria 01/2022 - 01/2002
24	Infections 01/2021 - 12/2006
5	Rupture 04/2020 - 04/2002
5	Falciparum Malaria (Plasmodium falciparum Malaria) 10/2018 - 02/2012
4	Parasitemia 12/2017 - 01/2007
3	COVID-19 10/2021 - 08/2020
3	Communicable Diseases (Infectious Diseases) 05/2014 - 07/2010
2	Pneumonia (Pneumonitis) 10/2021 - 12/2020
2	Elephantiasis 01/2017 - 01/2017
2	Filarial Elephantiasis (Lymphatic Filariasis) 01/2017 - 01/2017
2	Burkitt Lymphoma (Burkitt's Lymphoma) 08/2013 - 04/2012
2	Cerebral Malaria 03/2010 - 01/2007
1	Fever (Fevers) 01/2022
1	Pneumothorax 12/2020
1	Iron Deficiencies 01/2020
1	Chronic Hepatitis C 12/2017
1	Neoplasms (Cancer) 01/2017
1	Filariasis 01/2017
1	Human Influenza (Influenza) 01/2016
1	Birth Weight (Birth Weights) 06/2013
1	Sepsis (Septicemia) 05/2013
1	Cholera 02/2013
1	Anemia 11/2012
1	Bites and Stings (Sting) 12/2011
1	Encephalitis (Encephalitis, Rasmussen) 12/2011
1	Vivax Malaria 06/2011

Drug/Important Bio-Agent (IBA)

25	VaccinesIBA 01/2022 - 12/2002
19	AntigensIBA 01/2022 - 12/2006
13	AntibodiesIBA 01/2022 - 02/2006
13	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2010
11	Antimalarials (Antimalarial Agents)IBA 01/2020 - 11/2003
8	Immunoglobulin G (IgG)IBA 12/2017 - 02/2006
6	Malaria VaccinesIBA 11/2016 - 04/2002
6	Merozoite Surface Protein 1 (MSA1)IBA 11/2016 - 11/2007
5	Serine (L-Serine)FDA Link 04/2021 - 12/2006
5	artemisinin (artemisinine)IBA 04/2021 - 01/2011
5	hemozoinIBA 06/2017 - 01/2005
4	Surface Antigens (Surface Antigen)IBA 01/2022 - 02/2010
4	Plasmodium serine repeat antigenIBA 04/2012 - 04/2002
4	Orotate PhosphoribosyltransferaseIBA 02/2012 - 04/2004
4	Toll-Like Receptors (Toll-Like Receptor)IBA 12/2011 - 01/2007
3	Pharmaceutical PreparationsIBA 02/2020 - 05/2014
3	Heme (Haem)IBA 01/2020 - 01/2005
3	EnzymesIBA 08/2013 - 02/2005
3	Carboxy-LyasesIBA 06/2006 - 06/2004
3	orotidylic acidIBA 06/2006 - 06/2004
3	pyrimidineIBA 02/2005 - 04/2004
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2022 - 06/2011
2	Chloroquine (Aralen)FDA LinkGeneric 02/2020 - 01/2019
2	IronIBA 01/2020 - 11/2012
2	Biomarkers (Surrogate Marker)IBA 12/2017 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 06/2017 - 01/2005
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2017 - 02/2013
2	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 11/2016 - 08/2014
2	DNA (Deoxyribonucleic Acid)IBA 02/2013 - 01/2010
2	AluminumIBA 01/2013 - 09/2010
2	Hydroxyl RadicalIBA 01/2013 - 09/2010
2	Vaccine AdjuvantsIBA 12/2011 - 01/2010
2	Ferredoxins (Ferredoxin)IBA 12/2007 - 03/2007
2	Oxidoreductases (Dehydrogenase)IBA 12/2007 - 03/2007
2	EstersIBA 10/2004 - 11/2003
1	Oxygen (Dioxygen)IBA 10/2021
1	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 04/2021
1	ArtesunateIBA 01/2021
1	SteroidsIBA 12/2020
1	Indicators and Reagents (Reagents)IBA 08/2020
1	Blood Proteins (Serum Proteins)IBA 04/2020
1	Lumefantrine FDA Link 02/2020
1	allylpyrocatecholIBA 01/2020
1	Atovaquone (Mepron)FDA Link 01/2019
1	Pyrimethamine (Daraprim)FDA Link 01/2019
1	Mefloquine (Lariam)FDA LinkGeneric 01/2019
1	Biological ProductsIBA 04/2018
1	Leukocyte Immunoglobulin-like Receptor B1IBA 12/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Antimicrobial Cationic PeptidesIBA 01/2017
1	HLA-DRB1 Chains (HLA DRB1)IBA 10/2016
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2016
1	Tetanus Toxoid (Vaccine, Tetanus)FDA Link 08/2013
1	Histidine (L-Histidine)FDA Link 08/2013
1	Immunoglobulins (Immunoglobulin)IBA 08/2013
1	RibitolIBA 05/2013
1	16S Ribosomal RNAIBA 02/2013
1	Lipocalin-2IBA 11/2012
1	Neutralizing AntibodiesIBA 06/2012
1	ToxoidsIBA 06/2012
1	GibberellinsIBA 01/2012
1	Phosphotransferases (Kinase)IBA 12/2011
1	A-Form DNA (A-DNA)IBA 12/2011
1	InterferonsIBA 12/2011
1	Interferon Type IIBA 12/2011
1	DNA VaccinesIBA 12/2011

Therapy/Procedure

9	Therapeutics 01/2022 - 03/2010
2	Mass Drug Administration 01/2017 - 01/2017
1	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 12/2020
1	Mechanical Ventilators (Ventilator) 12/2020
1	Extracorporeal Membrane Oxygenation 12/2020
1	Optical Devices 01/2020
1	Insecticide-Treated Bednets 01/2020
1	Oral Administration 07/2019